Goal
Genome-scale metabolic models (GEMs) are a mathematical representation of organism-specific metabolism. Constraint-based analyses of GEMs can be used to investigate metabolic phenomena under diverse conditions in-silico. Community standards for consistent model reconstruction, curation, and sharing are crucial to ensure reproducibility, reliability, and FAIR sharing of the models. MEMOTE was previously developed to address some of these challenges as a community tool for standardised quality assessment of the models. However, it is difficult to assess whether constraint-based models, including GEMs, are reproducible because they often have multiple solutions, and their numerical values are not always enumerated in the published manuscripts. FROG is a community effort for standardised assessment of model reproducibility.
